Roles of Vascular and Metabolic Components in Cognitive Dysfunction of Alzheimer disease: Short- and Long-term Modification by Non-genetic Risk Factors
It is well known that a specific set of genetic and non-genetic risk factors contributes to the onset of Alzheimer disease (AD).Non-genetic risk factors include diabetes, hypertension in mid-life, and probably dyslipidemia in mid-life.This review focuses on the vascular and metabolic components of non-genetic risk factors.The mechanisms whereby non